I've tried a few so far. I went 5-3 with a BG self-mill midrange deck where I would gain value with escape creatures. I was missing some ramp and early removal and aggro decks beat me.
Then I tried a UR tokens/tempo deck which also went 5-3. The highlights were Young Pyro and Saheeli along with
Hellrider. I lost to the mirror (1 damage away!) and some slower decks that were able to stop my aggression.
I had a really sweet RW tokens deck, with lots of one and two drops and
Hellrider,
Castle Embreth and
Heroic Reinforcements and burn. I went 2-3 losing out to a bunch of slower decks. While I had aggro creatures, they always seem to have a 1/3 or something to slow me down enough that they could take over. It was frustrating because it felt I was always a play away from winning, but then something happened. My creatures did not have evasion and I think it was my downfall.
This last one I have, I am currently 3-0 with a 5 color blue based pile. I have cheap interaction and filtering, I have some mana rocks and a few road blocks and my top end is Golos,
Chamber Sentry, Nicol Bolas (the 4 drop dude),
Dinrova Horror,
Shipwreck Dowser and
Huatli, Warrior Poet. As stupid as it sounds, these big dudes are amazing at just holding people back and/or attacking for the win. Games have not felt close so far.
I've found that drafting around synergy to be tough. I will now focus on drafting good cards and if some synergy pieces arrive later in the pack, then I move in. Bombs -> fixing -> cheap interaction seems to work decently!