So, one card for each 2-colour combination:
Azorius: I agree with the others, Time Wipe
is unnecessary if you could just play Wrath/DoJ/Doomskar/...
Dimir: I don't like Silumgar's hexproof, while Ojutai is interesting since if you want to attack you have to put his shield down, Silumgar is just there with his asymmetrical nausea effect and the opponent can't do much. Then, maybe I hate too much hexproof
Rakdos: yeah the Cackler is the one I would cut. KCommand is exactly what I want a multicoloured card to be, and Kroxa is a nice card
Gruul: Xenagos seems bad(?) Idk I never played with it, but Atarka and Wrenn are on two other levels
Selesnya: Advent of the Wurm could be anything else in just green, like Elephant Ambush
Orzhov: Damn? It's a nice split card, but I notice that usually when I draft it, it gets passed by players with white that don't notice that it's just a Wrath of God with upside...
Izzet: Blistercoil Weird unless you do strange combos with it
Golgari: Garruk is underwhelming with respect to the others. Also, you could cut Grisly Salvage for Mulch
and add something like Pernicious Deed
Boros: Warleader's Helix is simply bad
Simic: is BtL really a Simic card? I would put it under 5-colour since well, usually you want to cast it for at least 3 or 4... paying 5 mana to tutor up a 2-drop is bad